This new course covers aspects of bio-molecular function and the interface with synthetic nanomaterials to explore the possibility of devices and systems that are unprecedented in nature. Within a lecture-and-discussion format, senior undergraduates and graduates will learn the principles of design of biological nanosystems, will be able to critically respond to the engineering issues surrounding the creation of nanobots, and will be able to appreciate their potential benefit and impact in health, agricultural, industrial and human environments.